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Risks of Infertility therapy? (2)
Title: A Danish national cohort of 730 infants born after
intracytoplasmic sperm injection (ICSI)
1994-1997
Author: A. Loft, et al.
Address: Copenhagen, Denmark
Source: Human Reproduction 14: 2143-2148 (August) 1999
Summary: The purpose of this study was to evaluate the pregnancy outcome
and the health of all children born after ICSI performed in Denmark between
January 1994 and July 1997. Laboratory and clinical data were collected from the
fertility clinics and the couples answered a questionnaire regarding the
pregnancy and the health of the child. The mean number of embryos replaced was
2.3 and in 95% of cases fresh embryos were transferred. Only 183 women (28.5%)
underwent prenatal diagnosis, resulting in 209 karyotypes with 7 (3.3%)
chromosome aberrations. Six major chromosomal abnormalities (2.9%) and 1
inherited structural chromosome aberration (0.5%) were found, but no sex
chromosome aberrations. In 2.2% of the liveborn infants, and in 2.7% of all
infants, the parents reported major birth defects. Minor birth defects were found
in 9 liveborn infants. Earlier studies found no different obstetric outcome after
ICSI compared with conventional in-vitro fertilization, and concluded that there
seems to be no higher incidence of congenital malformations in children born
after ICSI. The results of this study on outcome of ICSI pregnancies are in line
with those earlier reports, except that no chromosome abnormalities were found.
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